|
Azoospermia
|
0.200 |
Biomarker
|
disease |
BEFREE |
From these, sperm from 40 randomly selected men with no DAZ microdeletions in their leukocytes (n = 10 oligozoospermia; n = 10 asthenozoospermia; n = 10 oligoasthenozoospermia; and n = 10 near-azoospermia) were were compared to sperm from men of normal semen quality (n = 10) using combined primed in situ labelling and fluorescent in situ hybridization (PRINS-FISH) technique as well as screening for sex chromosome aneuploidy.
|
28521575 |
2018 |
|
Male infertility
|
0.200 |
Biomarker
|
phenotype |
BEFREE |
High frequency of de novo DAZ microdeletion in sperm nuclei of subfertile men: possible involvement of genome instability in idiopathic male infertility.
|
28521575 |
2018 |
|
Oligospermia
|
0.200 |
Biomarker
|
disease |
BEFREE |
From these, sperm from 40 randomly selected men with no DAZ microdeletions in their leukocytes (n = 10 oligozoospermia; n = 10 asthenozoospermia; n = 10 oligoasthenozoospermia; and n = 10 near-azoospermia) were were compared to sperm from men of normal semen quality (n = 10) using combined primed in situ labelling and fluorescent in situ hybridization (PRINS-FISH) technique as well as screening for sex chromosome aneuploidy.
|
28521575 |
2018 |
|
Asthenozoospermia
|
0.010 |
Biomarker
|
disease |
BEFREE |
From these, sperm from 40 randomly selected men with no DAZ microdeletions in their leukocytes (n = 10 oligozoospermia; n = 10 asthenozoospermia; n = 10 oligoasthenozoospermia; and n = 10 near-azoospermia) were were compared to sperm from men of normal semen quality (n = 10) using combined primed in situ labelling and fluorescent in situ hybridization (PRINS-FISH) technique as well as screening for sex chromosome aneuploidy.
|
28521575 |
2018 |
|
Oligoasthenozoospermia
|
0.010 |
Biomarker
|
disease |
BEFREE |
From these, sperm from 40 randomly selected men with no DAZ microdeletions in their leukocytes (n = 10 oligozoospermia; n = 10 asthenozoospermia; n = 10 oligoasthenozoospermia; and n = 10 near-azoospermia) were were compared to sperm from men of normal semen quality (n = 10) using combined primed in situ labelling and fluorescent in situ hybridization (PRINS-FISH) technique as well as screening for sex chromosome aneuploidy.
|
28521575 |
2018 |
|
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Analysis of partial azoospermia factor c deletion and DAZ copy number in azoospermia and severe oligozoospermia.
|
27739146 |
2016 |
|
Oligospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Analysis of partial azoospermia factor c deletion and DAZ copy number in azoospermia and severe oligozoospermia.
|
27739146 |
2016 |
|
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In men with AZFc subdeltions, loss of two DAZ and one CDY1 gene copy made them highly susceptible to azoospermia and severe oligozoospermia with OR of 29.7 and 26, respectively.
|
26149076 |
2015 |
|
Azoospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
More interestingly, partial DAZ1/2 deletion was associated with azoospermia (ORs=2.63, 95%CI: 1.19-5.81, I(2)=64.7%) and oligozoospermia (ORs=2.53, 95%CI: 1.40-4.57, I(2)=51.8%), but partial DAZ3/4 deletion was not associated with azoospermia (ORs=0.71, 95%CI: 0.23-2.22, I(2)=71.7%,) and oligozoospermia (ORs=1.21, 95%CI: 0.65-2.24, I(2)=55.5%).
|
26232607 |
2015 |
|
Male infertility
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
The purpose of this study was to determine the association of AZFc subdeletions (gr/gr, b1/b3 and b2/b3) and deletion of DAZ and CDY1 gene copies with male infertility
|
26149076 |
2015 |
|
Male infertility
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
In our meta-analysis, partial DAZ1/2 deletion is a risk factor for male infertility and different ethnicities have different influences, whereas partial DAZ3/4 deletion has no effect on fertility but partial DAZ3/4 deletion might have an impact on Non-East Asian male.
|
26232607 |
2015 |
|
Oligospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In men with AZFc subdeltions, loss of two DAZ and one CDY1 gene copy made them highly susceptible to azoospermia and severe oligozoospermia with OR of 29.7 and 26, respectively.
|
26149076 |
2015 |
|
Oligospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
More interestingly, partial DAZ1/2 deletion was associated with azoospermia (ORs=2.63, 95%CI: 1.19-5.81, I(2)=64.7%) and oligozoospermia (ORs=2.53, 95%CI: 1.40-4.57, I(2)=51.8%), but partial DAZ3/4 deletion was not associated with azoospermia (ORs=0.71, 95%CI: 0.23-2.22, I(2)=71.7%,) and oligozoospermia (ORs=1.21, 95%CI: 0.65-2.24, I(2)=55.5%).
|
26232607 |
2015 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this context, we investigated the expression of two known cancer testis genes, Aurora kinase C (AURKC) and testis expressed 101 (TEX101), and one new candidate, deleted in azoospermia 1 (DAZ1), in six breast cancer cell lines including two ductal carcinomas, T47D and BT-474, and four adenocarcinomas, MDA-MB-231, MDA-MB-468, MCF7, and SKBR3 as well as 50 breast cancer tumors in comparison to normal mammary epithelial cells using quantitative real-time reverse transcription PCR (RT-PCR).
|
25994570 |
2015 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this context, we investigated the expression of two known cancer testis genes, Aurora kinase C (AURKC) and testis expressed 101 (TEX101), and one new candidate, deleted in azoospermia 1 (DAZ1), in six breast cancer cell lines including two ductal carcinomas, T47D and BT-474, and four adenocarcinomas, MDA-MB-231, MDA-MB-468, MCF7, and SKBR3 as well as 50 breast cancer tumors in comparison to normal mammary epithelial cells using quantitative real-time reverse transcription PCR (RT-PCR).
|
25994570 |
2015 |
|
Male infertility
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Analysis of DAZ gene copies in Tunisian population, suggested that the simultaneous deletion of DAZ2 and DAZ4 gene copies is associated with male infertility, and that oligospermia seems to be promoted by removing DAZ4 copy.
|
24878370 |
2014 |
|
Oligospermia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Analysis of DAZ gene copies in Tunisian population, suggested that the simultaneous deletion of DAZ2 and DAZ4 gene copies is associated with male infertility, and that oligospermia seems to be promoted by removing DAZ4 copy.
|
24878370 |
2014 |
|
Azoospermia
|
0.200 |
Biomarker
|
disease |
BEFREE |
The AZFc(azoospermia factor c)/DAZ (deleted in azoospermia) duplications might underlie the susceptibility of Y-hg K* to spermatogenic impairment.
|
23696539 |
2013 |
|
Male infertility
|
0.200 |
GeneticVariation
|
phenotype |
BEFREE |
Analysis of DAZ gene copies in AZFc microdeletions suggests that the contribution of the different deletions to male infertility varies.
|
23512232 |
2013 |
|
Non-obstructive azoospermia
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
DAZ duplications confer the predisposition of Y chromosome haplogroup K* to non-obstructive azoospermia in Han Chinese populations.
|
23696539 |
2013 |
|
Congenital absence of germinal epithelium of testes
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Partial AZF deletions including single AZF Y genes can cause the same testicular pathology as the corresponding complete deletion (e.g., DDX3Y gene deletions in AZFa), or might not be associated with male infertility at all (e.g., some BPY2, CDY1, DAZ gene deletions in AZFc).
|
22992914 |
2013 |
|
Multiple Chronic Conditions
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, we quantified the multi-copy DAZ gene, which has variable copy numbers between individuals and plays an important role in spermatogenesis.
|
23696539 |
2013 |
|
Oligospermia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Transmission of DAZ (Deleted in Azoospermia) microdeletion is one of the major concerns for oligo and severe oligozoospermia patients.
|
22648284 |
2012 |
|
Oligospermia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Although AZFc is deleted in azoospermia or oligozoospermia, no definitive conclusion has been drawn for the role of partial AZFc deletions to spermatogenic failure.
|
20823911 |
2011 |
|
Congenital absence of germinal epithelium of testes
|
0.060 |
Biomarker
|
disease |
BEFREE |
A total of 11 patients with sertoli cell-only syndrome (SCOS) and 5 oligospermic patients with gr/gr subdeletions also have DAZ1/DAZ2 genes deleted indicating that deletions of DAZ genes contributed differently to damage to spermatogenic process.
|
20823911 |
2011 |